- 商品介绍
- 规格参数
- 包装参数
General description
Casein kinase 1 δ (CK1δ) is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair.
Biochem/physiol Actions
CK1δ is a regulator of Yes-associated protein (YAP) transcription coactivator, which is a key regulator of organ size and a candidate human oncogene. CK1d is activated by CCK2R and it then phosphorylates polycystin 2 (PKD2) at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CKId can phosphorylate in vitro deoxycytidine kinase (dCK), which is a key enzyme in the salvage of deoxynucleosides. Phosphorylation of dCK by CKId in vitro correlates with increased activity of this enzyme.
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| recombinant | expressed in baculovirus infected Sf9 cells |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 70-94 nmol/min·mg |
| mol wt | ~72 kDa |
| NCBI accession no. | NM_001893 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... CSNK1D(1453) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 1669.50
-
询价
-
询价
-
询价
-
询价
-
¥ 1349.07
-
¥ 1524.91
-
¥ 5762.83
-
¥ 4110.85
-
¥ 1327.84
-
¥ 968.94
-
¥ 1540.85
-
¥ 2005.84
-
¥ 2170.40
-
¥ 70526.15
-
¥ 30616.15
-
询价
-
询价
-
询价
微信小程序
7X24小时在线咨询