- 商品介绍
- 规格参数
- 包装参数
General description
Anti-C-RAF Antibody detects endogenous levels of total C-RAF protein.
Raf-1 proto-oncogene, serine/threonine kinase (RAF1) or C-RAF is an anti-apoptotic protein. The gene encoding it is localized on human chromosome 3p25.2.
Immunogen
The antiserum was produced against synthesized peptide derived from human C-RAF.
Immunogen Range: 271-320
Biochem/physiol Actions
Raf-1 proto-oncogene, serine/threonine kinase (RAF1) or C-RAF is a crucial component of the Raf/mitogen-activated extracellular signal-regulated kinase (MEK)/extracellular regulated protein kinase (ERK) signaling cascade. It functions as an activator of MEK-1 and -2. The protein is upregulated in many cancers. Mutations in the gene encoding RAF1 have been linked to Noonan syndrome.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen 73 kDa |
| species reactivity | mouse, human, rat |
| concentration | ~1 mg/mL |
| technique(s) | ELISA: 1:40000,immunohistochemistry: 1:50-1:100,western blot: 1:500-1:1000 |
| NCBI accession no. | P04049 |
| UniProt accession no. | P04049 |
| shipped in | wet ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... RAF1(5894) |
| 长度(mm) | |
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