地塞米松-21-磷酸二钠盐二钠盐，100MG，D1159-100MG，Sigma

销售价： ¥ 544.83 / 件

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订货号： 0BL3199

品牌型号： Sigma D1159-100MG

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

Application

Dexamethasone 21-phosphate disodium salt has been used:

as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 (HSV-1) in the induced reactivation (IR) and spontaneous shedding (SS) rabbit models
as a receptor analog to study its effects on glucocorticoid receptor activation in suprachiasmatic nuclei (SCN)-lesioned mice
to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs

Biochem/physiol Actions

Dexamethasone 21-phosphate (Dex 21-P) is a pro-drug that can undergo dephosphorylation to form dexamethasone with the help of intra-erythrocyte enzymes. It exhibits therapeutic effects against cystic fibrosis and postoperative cataract. Dex 21-P disodium salt is a synthetic adrenal corticosteroid and possesses anti-inflammatory activity.

技术参数 Specifications

Quality Level	100
assay	≥98%
form	powder
impurities	≤1% ethanol
color	white to off-white
storage temp.	2-8°C
SMILES string	[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O
InChI	1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
InChI key	PLCQGRYPOISRTQ-FCJDYXGNSA-L
Gene Information	human ... NR3C1(2908)