- 商品介绍
- 规格参数
- 包装参数
General description
TDP-43 (TAR DNA binding protein) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs), that binds single stranded RNA. TDP-43 has been implicated in the transcription regulation of HIV. TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype FTLD-U and amyotrophic lateral sclerosis (ALS). TDP-43 is predominantly localized to the nucleus.
Immunogen
synthetic peptide containing phosphorylated Ser410 of human TDP-43, conjugated to KLH. The corresponding sequence is identical in mouse TDP-43.
Application
Anti-phospho-TDP-43 (pSer410) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Several pathogenic TDP-43 mutations have been identified in familial amyotrophic lateral sclerosis (ALS).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~43 kDa |
| species reactivity | mouse, human |
| concentration | ~1.0 mg/mL |
| technique(s) | western blot: 1-2 μg/mL using HepG2 and NIH3T3 cell lysates |
| UniProt accession no. | Q13148 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer410) |
| Gene Information | human ... TARDBP(23435) mouse ... Tardbp(230908) |
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¥ 1259.40
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¥ 2019.57
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¥ 1451.54
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¥ 3812.28
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¥ 14407.09
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¥ 8982.64
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¥ 2617.87
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¥ 745.60
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