- 商品介绍
- 规格参数
- 包装参数
General description
CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition.
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
| recombinant | expressed in baculovirus infected Sf9 cells |
| product line | PRECISIO® Kinase |
| assay | ≥70% (SDS-PAGE) |
| form | buffered aqueous glycerol solution |
| specific activity | 70-95 nmol/min·mg |
| mol wt | ~58 kDa (CDK1), ~81 kDa (CyclinA1) |
| NCBI accession no. | BC036346,NM_001798 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... CCNA1(8900), CDK2(1017) |
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¥ 1596.77
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¥ 9207.92
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¥ 4039.86
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¥ 1724.25
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¥ 1956.41
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¥ 6894.69
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¥ 5725.45
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¥ 4897.21
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¥ 2617.87
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¥ 5061.38
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