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- 规格参数
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General description
C-X-C motif chemokine receptor 1 (CXCL1) is also known as keratinocyte-derived chemokine (KC). It is part of the glutamate-leucine-arginine (ELR)-containing CXC chemokine family. Recombinant Murine KC (CXCL1) is a 7.8kDa protein consisting of 72 amino acids including the ‘ELR′ motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
Application
C-X-C motif chemokine receptor 1 (CXCL1) from mouse has been used in transwell assay for chemotaxis.
Biochem/physiol Actions
All three isoforms of growth-related protein (GRO) are CXC chemokines that can signal through C-X-C motif chemokine receptors 1 or 2 (CXCR1 or 2). The GRO proteins chemoattract and activate neutrophils and basophils. It has a role in host defense against polymicrobial sepsis, upregulation of intercellular adhesion molecule 1 (ICAM-1) and migration of neutrophils. The protein also activates mitogen-activated protein kinases (MAPKs), pro-inflammatory proteins and nuclear factor-κB (NF-κB).
Physical form
Lyophilized with no additives.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Other Notes
APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK
| biological source | mouse |
| recombinant | expressed in E. coli |
| assay | ≥98% (HPLC),≥98% (SDS-PAGE) |
| form | lyophilized |
| mol wt | 7.8 kDa |
| packaging | pkg of 20 μg |
| technique(s) | cell culture | mammalian: suitable |
| impurities | <0.1 EU/μg endotoxin, tested |
| color | off-white to yellow |
| UniProt accession no. | P12850 |
| shipped in | wet ice |
| storage temp. | −20°C |
| Gene Information | mouse ... CXCL1(14825) |
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¥ 1048.84
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmSFCA滤膜，孔径0.2um,适合瓶颈尺寸45mm，12/箱，291-4520，Nalgene，Thermofisher，赛默飞世尔¥ 1142.57
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瓶顶过滤器-500ml容量,MF75TM系列，聚苯乙烯外壳，75mmPES滤膜，孔径0.45um,适合瓶颈尺寸33mm，12/箱，295-3345，Nalgene，Thermofisher，赛默飞世尔¥ 775.42
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