- 商品介绍
- 规格参数
- 包装参数
产品介绍
Product Description
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规格 |
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| Accession Number: | NP_002746, S218D, S222D |
| Assay Entry: | Biochemical binding/kinetic |
| Kinase Group: | Ser⁄Thr Kinases: STE Group |
| Mass: | 10 µg |
| Shipping Condition: | Dry Ice |
| Tag Position: | N-Terminal |
| Target Entry: | MAP2K1 S218D S222D |
| Target Gene: | Mitogen-activated protein kinase kinase 1 |
| Expression System: | Baculovirus |
| Protein Family: | Kinases & Inhibitors |
| Protein Form: | Full Length, Recombinant |
| Protein Subtype: | Serine⁄Threonine Kinases |
| Research Category: | Signal Transduction |
| Species: | Human |
| Validated Application: | Kinase Assay |
| Gene ID (Entrez): | 5604 |
| Molecular Weight: | 49.2 kDa |
| Gene Alias: | MAP2K1 (MEK1) S218D S222D |
| KinaseFamily: | STE7 Kinase Family |
| Protein Tag: | His Tag |
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储存 |
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Storage Buffer: 50 mM Tris, pH 7.5, 150 mM NaCl, 0.05 mM EDTA, 0.05% NP-40, 1mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws. |
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描述 |
MAP2K1 (MEK1) kinse is a dual-specific protein kinase that functions in mitogen-activated protein kinase (MAPK) cascades, controlling cell growth and differentiation. MAP2K1 is activated by a wide variety of growth factors and cytokines and also by membrane-dependent depolarization and calcium influx. This mutant has been activated by subsituting serines 218 and 222 with aspartic acid to mimic the phosphorylated state.
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