- 商品介绍
- 规格参数
- 包装参数
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规格 |
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| Accession Number: | NP_940980.3 |
| Protein Form: | Full Length |
| Research Category: | Neurobiology |
| Species: | Human |
| Molecular Weight: | 288 kDa |
| Gene Alias: | AURA17, DARDARIN, PARK8, RIPK7, ROCO2 |
| Validated Application: | Kinase Assay |
| Expression System: | Mammalian |
| KinaseFamily: | LRRK Kinase Family |
| Protein Tag: | DYKDDDDK |
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储存 |
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Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase. Suspended in: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton®X–100, 2 mM DTT, and 50% glycerol. |
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描述 |
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.
• Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds or hits specific to the full-length form
• Advance Parkinson's research using the full-length protein and validated assays
Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® TR-FRET Kinase Activity Assay
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