规格
Accession Number:	NP_940980.2, G2019S
Assay Entry:	Biochemical ADP accumulation, Biochemical terbium phospho-specific activity, Biochemical binding/kinetic
Kinase Group:	Ser⁄Thr Kinases: TKL Group
Protein Form:	Recombinant, Catalytic
Research Category:	Signal Transduction, Neurobiology
Shipping Condition:	Dry Ice
Species:	Human
System Compatibility:	LanthaScreen® Antibody, LanthaScreen® Substrate, Adapta™
Target Entry:	LRRK2 G2019S
Target Gene:	Leucine-rich repeat kinase 2
Gene ID (Entrez):	120892
Molecular Weight:	204.9 kDa
Quantity:	10μg
Protein Subtype:	Serine⁄Threonine Kinases
Gene Alias:	LRRK2 G2019S
Validated Application:	Kinase Assay
Protein Family:	Kinases & Inhibitors
Expression System:	Baculovirus
KinaseFamily:	LRRK Kinase Family
Protein Length:	aa 970-2527; G2019S
Protein Tag:	GST Tag

储存
Storage Buffer: 50 mM Tris pH 7.5, 150 mM NaCl, 0.5 mM EDTA, 0.02% Polysorbate 20, 2 mM DTT, 50% glycerol Store at -80°C. At first use, aliquot and store at -80°C to avoid multiple freeze-thaws.

描述

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in this gene have been associated with Parkinson's disease. The G2019S mutation of LRRK2 is associated with an increase in catalytic activity.

Related Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen® Eu Kinase Binding Assay
• LanthaScreen® Activity Assay

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