IRF-4 Antibody, anti-human/mouse, Vio® B515, REAfinity™，130-130-967，美天旎

Clone REA201 recognizes IRF-4, which is a 52 KDa transcription factor and belongs to the family of interferon regulatory transcription factors (IRF).The IRF family consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain (DBD) with unique tryptophan pentad repeat and modulates the expression of genes regulated by the presence of interferons and in response to cell activation. Expression of IRF-4 is found in cells of the immune system, including lymphocytes, dendritic cells, and macrophages, where it's multiple functions include regulation of cell proliferation, apoptosis, and differentiation. Transcriptional activity of IRF-4 is further modulated by its interaction with various co-factors including including Pu.1, E47, STAT-6, and IRF-8.

Additional information: Clone REA201 displays negligible binding to Fc receptors.

IRF4, LSIRF, MUM1, NF-EM5, SHEP8, LSIRF, Spip, LSIRF13, ICSAT14

Technical specifications