- 商品介绍
- 规格参数
- 包装参数
General description
Fibulin-5 (also known as EVEC/DANCE) is an extracellular matrix protein. Fibulin-5 is most commonly found in blood vessels and cardiac valves during embryogenesis and in adult tissue that contains elastic fibers like the skin, lungs, uterus and aorta. Fibulin-5 travels to the surface of the elastic fibers and its activity is dependent on calcium. Fibulin-5 seems to work as a scaffold protein that facilitates the binding of the elastic fibers to cells and the formation of the elastic fibers themselves. Mutations of fibulin-5 have been associated with age-related macular degeneration (AMD) and cutis laxa (CL).
~54 kDa observed.
The calculated molecular weight is 50 kDa; however bands have been observed at ~56 kDa (Freeman, L.J., et al. (2005) Biochem. J. 388:1-5).
Immunogen
Epitope: Near C-terminus
KLH-conjugated linear peptide corresponding to human Fibulin-5 near the C-terminus.
Application
Anti-Fibulin-5 Antibody detects level of Fibulin-5 & has been published & validated for use in WB.
Research Category
Cell Structure
Research Sub Category
ECM Proteins
Biochem/physiol Actions
This antibody recognizes Fibulin-5 near the C-terminus.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse heart tissue lysate
Evaluated by Western Blot in mouse heart tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected Fibulin-5 in 10 µg of mouse heart tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human, mouse, rat |
| species reactivity (predicted by homology) | rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_006320 |
| UniProt accession no. | Q9UBX5 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... FBLN5(10516) |
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¥ 1563.36
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¥ 1573.49
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¥ 4039.86
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¥ 5887.85
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¥ 3812.28
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¥ 1749.15
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¥ 3662.39
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¥ 66743.99
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