- 商品介绍
- 规格参数
- 包装参数
General description
A cis-polyunsaturated fatty acid found in the plasma membrane. Major component of membrane phospholipids. Following its release by cellular phospholipases, it is enzymatically converted to a variety of inflammatory and vasoactive metabolites, such as prostaglandins (via the cyclooxygenase pathway), leukotrienes (via the lipoxygenase pathway), and epoxides (via the cytochrome P450 pathway). Binds to G-protein α-subunits in a covalent, posttranslational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets.
Precursor for prostaglandins, prostacyclin, and thromboxane. Binds to G-protein α-subunits in a covalent, post-translational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets. Modulates nitric oxide production by prostaglandin synthesis via the cyclooxygenase pathway.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Ras-GAP
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Hallak, H., et al. 1994. J. Biol. Chem. 269, 4713.
Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480.
Han, J.-W., et al. 1991. Science252, 576.
Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325.
Neddleman P., et al. 1986. Annu. Rev. Biochem.55, 69.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
| description | Merck USA index - 14, 765 |
| Quality Level | 100 |
| assay | ≥99% (TLC and GC) |
| form | oil |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | colorless |
| solubility | ethanol: 5 mg/mL |
| shipped in | dry ice |
| storage temp. | −70°C |
| SMILES string | OC(=O)CCC\C=C\C\C=C\C\C=C\C\C=C\CCCCC |
| InChI | 1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6+,10-9+,13-12+,16-15+ |
| InChI key | YZXBAPSDXZZRGB-CGRWFSSPSA-N |
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¥ 2068.25
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¥ 9207.92
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¥ 2883.61
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¥ 8982.64
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¥ 2666.57
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¥ 1196.00
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¥ 1749.15
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¥ 2869.87
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