- 商品介绍
- 规格参数
- 包装参数
General description
Src Homology region 2 domain Phosphatase 1 (SHP-1) is also known as Protein Tyrosine Phosphatase 1C (PTP1C), Protein Tyrosine Phosphatase non-receptor type 6 (PTPN6), and Hematopoietic Cell Phosphatase (HCPH). SHP-1 is a SH2 domain-containing cytosolic tyrosine phosphatase characterized by a catalytic phosphatase domain of approximately 240 amino acids that selectively dephosphorylates tyrosine residues in proteins; the SH2 domains are critical for SHP-1 to bind to ITIM domains in inhibitory immunoreceptors. SHP-1 is highly expressed in hematopoietic tissues and has a negative impact on lymphocyte signaling. SHP-1 is implicated in the control of tyrosine kinase signaling pathways in cellular proliferation, with a potential role in cancer.
~67 kDa observed.
3 isoforms exist with molecular weights between 63 kDa and 68 kDa
Immunogen
Full-length glutathione transferase SHP-1 fusion protein, purified from bacteria.
Application
Anti-SHP-1 Antibody, clone HG213 detects level of SHP-1 & has been published & validated for use in WB.
Research Category
Cell Structure
Research Sub Category
Cytoskeletal Signaling
Physical form
Rabbit monoclonal supernatant without sodium azide.
Unpurified
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
Jurkat cell lysate
Evaluated by Western Blot in Jurkat cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected SHP-1 in 10 µg of Jurkat cell lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | unpurified |
| antibody product type | primary antibodies |
| clone | HG213, monoclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_002822 |
| UniProt accession no. | P29350 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... PTPN6(5777) |
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