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General description
Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.
~62-80 kDa observed. The calculated molecular weight of this protein is 62 kDa, but can run as high as 80 kDa due to PTM.
Immunogen
MAP peptide corresponding to human BAG3.
Application
Anti-BAG3 Antibody, clone AC-2 detects level of BAG3 & has been published & validated for use in Western Blotting.
Immunoprecipitation Analysis: A 1:500 dilution from a representative lot detected BAG3 IP′d from 500 µg of HeLa lysate.
Research Category
Apoptosis & Cancer
Research Sub Category
Chaperones
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
HeLa cell lysate
Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: A 1:1000 dilution of this antibody detected BAG3 in 10 µg of HeLa cell lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | AC-2, monoclonal |
| species reactivity | human |
| technique(s) | western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_004272 |
| UniProt accession no. | O95817 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... BAG3(9531) |
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