Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5,200UG,05-786,Sigma

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订货号 : 0BW1413
品牌型号 : Sigma 05-786
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最小订货量 : 1件
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产品介绍 Product Description

General description

SMC1 is a ATPase and subunit of the multiprotein cohesin complex, a protein involved in chromosome segregation and in double-strand DNA break (DSB) repair. Serine 957 is phosphorylated by ATM in response to DSBs and is involved in the S-phase DNA damage checkpoint.
Mr 150kDa


Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 951-962 (SQEEGS[pS]QGEDS) of human SMC1


Application

Detect phospho-SMC1 (Ser957) with Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 (Mouse Monoclonal Antibody), that has been shown to work in WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair


Biochem/physiol Actions

Predicted to cross-react with xenopus and bovine based on sequence homology
phospho-SMC1 (Ser957)


Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Purified


Preparation Note

2 years at -20°C


Analysis Note

routinely evaluated by immunoblot on RIPA lysates from irradiated GMO536 cells and hydroxyurea treated HEK293 cells


Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany


Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


技术参数 Specifications
biological sourcemouse
Quality Segment100
antibody formpurified antibody
antibody product typeprimary antibodies
clone5D11G5, monoclonal
species reactivitymouse, human
manufacturer/tradenameUpstate®
technique(s)western blot: suitable
isotypeIgG1
NCBI accession no.NM_006306
UniProt accession no.Q14683
shipped inwet ice
target post-translational modificationphosphorylation (pSer957)
Gene Informationhuman ... SMC1A(8243)
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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