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General description
Serine/threonine-protein kinase 39 (STK39), also known as STE20/SPS-1 related proline alanine-rich kinase (SPAK), is a member of the SPS1 subfamily of STE20 kinases. STK39 is also very highly conserved between species and has been shown to activate the p38 pathways. STK39 also has a caspase cleavage site and these two functions may mean that STK39 plays a role in stress-activated signaling. STK39 expression is up-regulated by androgens in LNCaP human prostate cancer cells and regulated and phosphorylated by WNK1, which controls the stress signaling pathway. It is activated by WNK4 and then has the ability to stimulate the Na-K-2Cl cotransporter, the inactive version does not possess this ability. Recent research has also made a connection between STK39 and regulation of blood pressure.
~60 kDa observed
Immunogen
Epitope: C-terminus
GST-tagged recombinant protein corresponding to the C-terminus of human STK39.
Application
Anti-STK39 Antibody, clone 5H7.1 is a highly specific mouse monoclonal antibody, that targets STK39 & has been tested in western blotting & IHC.
Research Category
Signaling
Research Sub Category
Developmental Signaling
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected STK39 in 10 µg of mouse and rat brain tissue lysate.
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected STK39 in human cerebellum sections and rat hindbrain sections tissue.
Biochem/physiol Actions
This antibody recognizes the C-terminus of STK39.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected STK39 in 10 µg of human brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 5H7.1, monoclonal |
| species reactivity | rat, human, mouse |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_037365 |
| UniProt accession no. | Q9UEW8 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... STK39(27347) |
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