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General description
Mutated melanoma-associated antigen 1 (MUM1), also known as Protein expandere and PWWP domain-containing protein MUM1. MUM1’s normal role is as a DNA and chromatin associated protein that is involved in the cell’s response to DNA damage. It is driven to DNA breaks by its interaction with another DNA chromatin protein, TP53BP1, which it binds. The binding facilitates chromatin relaxation and entry of DNA repair enzymes. MUM1 is required for efficient DNA repair and cellular survival after DNA damage. Interestingly MUM1 was first identified by cloning the chromosomal breakpoints of a multiple myeloma cell line and was identified as a member of the interferon response transcriptional factor gene family (IFR). MUM1 appears to play a critical role in cell proliferation, differentiation and survival of various cancers, as well as monocytes and dendritic cells. MUM1 is expressed in B cells and plasma cells as well and in some populations of T lymphocytes. EMD-Millipore’s Anti-MUM1 mouse monoclonal antibody has been tested in against recombinantly expressed human MUM1 protein and in paraffin embedded immunohistochemistry on human melanoma, non-Hodgkin’s lymphoma and normal uterus tissue sections.
~55 kDa observed
Immunogen
Purified recombinant fragment of human MUM1 expressed in E. Coli.
Application
Detect Mutated melanoma-associated antigen 1 using this mouse monoclonal antibody, Anti-MUM1 Antibody, clone 4G10 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected MUM1 in human uterus, melanoma, and non-Hodgkin`s lymphoma tissues.
Optimal working dilutions must be determined by end user.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Physical form
Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Unpurified
Preparation Note
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Evaluated by Western Blotting in recombinant MUM1 protein.
Western Blotting Analysis: A 1:500-2000 dilution of this antibody detected recombinant MUM1.
Control
Recombinant MUM1 protein
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | ascites fluid |
| antibody product type | primary antibodies |
| clone | 4G10, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1 |
| UniProt accession no. | Q2TAK8 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... PWWP3A(84939) |
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询价
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¥ 1011.55
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