- 商品介绍
- 规格参数
- 包装参数
General description
Relatively selective blocker of L-type Ca2+ channels. One of the most extensively studied blockers of 1,4-dihydropyridine-type Ca2+ channels, and a pharmacologically-useful vasodilator. Induces apoptosis in human glioblastoma cells.
Biochem/physiol Actions
Cell permeable: no
Primary Target
L-type Ca2+ channels
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, refrigerate (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Reid, K., et al. 1997. J. Pharmacol. Exp. Ther. 283, 993.
Kondo, S., et al. 1995. J. Neurosurg.82, 469.
Antkiewicz-Michaluk, L., et al. 1994. Eur. J. Pharmacol. 254, 9.
Calabresi, P., et al. 1994. J. Neurosci. 14, 4871.
Akman, M.S., et al. 1993. Endocrinology132, 1286.
Cirillo, M., et al. 1993. Circ. Res.72, 847.
Young, R.J., et al. 1993. Biochim. Biophys. Acta1146, 81.
Janis, R., et al. 1987. Adv. Drug Res.16, 311.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
| description | Merck USA index - 14, 6528 |
| Quality Level | 100 |
| assay | ≥98% (UV) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | yellow |
| solubility | DMSO: soluble,ethanol: soluble |
| shipped in | ambient |
| storage temp. | 10-30°C |
| SMILES string | [N+](=O)([O-])c1c(cccc1)C2C(=C(NC(=C2C(=O)OC)C)C)C(=O)OC |
| InChI | 1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 |
| InChI key | HYIMSNHJOBLJNT-UHFFFAOYSA-N |
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| 重量(kg) |
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¥ 1082.93
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¥ 580.62
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¥ 1243.80
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¥ 1316.02
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¥ 462.77
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