- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable and reversible PP1 analog that acts as a potent, selective, and ATP-competitive inhibitor of mutant kinases compared to the corresponding wild-type kinase (IC50 = 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µM for c-Fyn; 4.3 nM for I338G, v-src-as1 vs. 28 µM for v-src; 5 nM for F80G, CDK2-as1 vs. 29 µM for CDK2; 8 nM for F89G, CAMK IIa-as1 vs. 24 µM for CAMKII; 120 nM for T315A, c-Abl-as2 vs. 3.4 µM for c-Abl). Shown to activate mutants of Ire1, a transmembrane kinase.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
mutant c-Fyn, v-src, Cadk2, CaMKIIa, c-Abl etc.,
Reversible: yes
Target IC50: 3.2 nM for T339G, c-Fyn-as1 vs. 1.0 µ
Packaging
Packaged under inert gas
Physical form
A 10 mM (1 mg/302 µL) solution of PP1 Analog II, 1NM-PP1 (Cat. No. 529581) in DMSO.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -70°C.
Other Notes
Ira, G., et al. 2004. Nature431, 1011.
Papa, F.R., et al. 2003. Science302, 1533.
Bishop, A.C., et al. 2000. Nature407, 395.
Weiss, E.L., et al. 2000. Nat. Cell Biol.2, 677.
Bishop, A.C., et al. 1999. J. Am. Chem. Soc.121, 627.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,avoid repeated freeze/thaw cycles,desiccated (hygroscopic),protect from light |
| shipped in | dry ice |
| storage temp. | −70°C |
| SMILES string | [n]1(nc(c4c1ncnc4N)Cc2c3c(ccc2)cccc3)C(C)(C)C |
| InChI | 1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) |
| InChI key | GDQXJQSQYMMKRA-UHFFFAOYSA-N |
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¥ 3442.25
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¥ 2151.46
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔
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