- 商品介绍
- 规格参数
- 包装参数
General description
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.
Immunogen
Immunogen information for this antibody is proprietary information.
Application
This armenian hamster monoclonal antibody Anti-CD152 (CTLA-4) (mouse), PE & clone UC10-4F10-11 validated for use in Flow Cytometry for the detection of CD152 (CTLA-4).
Research Category
Inflammation & Immunology
Physical form
Purified Armenian Hamster Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Size Exclusion Chromatography
Preparation Note
It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Analysis Note
The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Flow Cytometry Analysis: 0.06 µg of this antibody detected CD152 (CTLA-4) in one million C57Bl/6 splenocytes.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | hamster (Armenian) |
| Quality Segment | 100 |
| conjugate | PE |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | UC10-4F10-11, monoclonal |
| species reactivity | mouse |
| concentration | 0.2 mg/mL |
| technique(s) | flow cytometry: suitable |
| isotype | IgG |
| UniProt accession no. | P09793 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Ctla4(12477) |
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¥ 1302.89
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¥ 3372.68
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¥ 20380.83
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¥ 2268.97
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¥ 2452.91
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¥ 1351.48
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¥ 5990.26
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