- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
Packaging
Packaged under inert gas
Preparation Note
Slight warming may be required for complete solubilization.
Other Notes
Outerio, T.F., et al. 2007. Science317, 516.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | yellow |
| solubility | DMSO: 2.5 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | Clc1c(cc(cc1)Cl)c2[o]c(cc2)\C=C(\C(=O)Nc3c4c(nccc4)ccc3)/C#N |
| InChI | 1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+ |
| InChI key | SVENPFFEMUOOGK-SDNWHVSQSA-N |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 625.35
-
询价
-
¥ 3683.17
-
询价
-
询价
-
¥ 689.70
-
询价
-
询价
-
¥ 462.77
-
¥ 314.94
-
¥ 1164.64
-
NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
-
询价
-
¥ 145427.01
-
¥ 17652.29
-
¥ 55311.07
-
¥ 58184.19
-
¥ 3704.60
-
¥ 99441.38
微信小程序
7X24小时在线咨询