- 商品介绍
- 规格参数
- 包装参数
General description
Ermin is also known as Juxtanodin (JN). Ermin is involved in cytoskeletal rearrangements during myelinogenesis and in the maintenance and stability of the myelin sheath in adults. Ermin is also thought to be important in oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the plasticity of related structures in the mature CNS. Ermin is exclusively expressed by oligodendrocytes in the brain and spinal cord, where it appears in the late stages of myelination, and in the mature nerves, it is localized in the outer cytoplasmic lip of the myelin sheath and the paranodal loops.
~42 kDa observed. The calculated molecular weight of this protein is 32 kDa; however, it has been observed at ~42 kDa (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-76.).
Immunogen
Recombinant protein corresponding to mouse Ermin.
Application
Anti-Ermin Antibody, clone 160 is a highly specific mouse monoclonal antibody, that targets Ermin & has been tested in western blotting, ICC & IHC.
Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Ermin in mouse wild type sagittal brain sections, and demonstrated a loss of signal in mouse OL-ablated sagittal brain sections (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-762).
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Ermin in certain mouse brain and optic nerve sections (Brockschnieder, D., et al. (2006). J Neurosci. 26(3):737-762).
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse brain tissue lysate
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected Ermin in 10 µg of mouse brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 160, monoclonal |
| species reactivity | mouse, rat |
| technique(s) | immunocytochemistry: suitable,immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG2aκ |
| NCBI accession no. | NP_084248 |
| UniProt accession no. | Q5EBJ4 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Ermn(77767) |
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