- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide (Cat. No. 376815). The internalization domain of the Antennapedia homeoprotein is fused to the methionine amino terminal. Shown to completely detach and translocate HXK2 from mitochondria to the cytosol in HeLa cells at 100 µM. Does not induce Bax translocation or cytochrome c release when used alone. However, it markedly sensitizes cells to cytochrome c release and to the induction of apoptosis when used in combination with a Bax-dependent apoptosis inducer, Indomethacin (Cat. No. 405268).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Detach and translocate HXK2 from mitochondria to the cytosol
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Other Notes
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Met-Ile-Ala-Ser-His-Leu-Leu-Ala-Tyr-Phe-Phe-Thr-Glu-Leu-Asn-NH₂
Pastorino, J.G., et al. 2002. J. Biol. Chem.277, 7610.
Holinger, E.P., et al. 1999. J. Biol. Chem.274, 13298.
Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys.345, 111.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| color | white |
| solubility | water: 1 mg/mL |
| shipped in | wet ice |
| storage temp. | −20°C |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
询价
-
¥ 9207.92
-
询价
-
询价
-
¥ 3442.25
-
¥ 1956.41
-
¥ 8520.40
-
¥ 8135.09
-
询价
-
¥ 6330.00
-
¥ 4897.21
-
询价
-
¥ 2617.87
-
¥ 1196.14
-
¥ 5061.38
-
¥ 1476.40
-
¥ 3031.24
-
¥ 4614.63
-
询价
-
¥ 145427.01
微信小程序
7X24小时在线咨询