- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Grant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA109, 4503.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | >92% (HPLC) |
| form | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | DMSO: 100 mg/mL |
| shipped in | wet ice |
| storage temp. | −20°C |
| SMILES string | N1c2c(cc4c(c2)OCO4)C(CC1=O)c3c(cccc3)OCC |
| InChI | 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20) |
| InChI key | YKSYGLXHLSPWLB-UHFFFAOYSA-N |
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