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General description
Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, results from autosomal dominant CCM1 mutations that cause a loss of KRIT-1 protein function. CCM1 has been identified as the KRIT-1 gene. The protein product, KRIT-1, also known as Krev interaction trapped protein 1, is a microtubule-associated protein involved in endothelial cell-cell and cell-extracellular matrix interactions. KRIT-1 binds to Rap1 that maintains the integrity of endothelial junctions. It is reported that KRIT-1 colocalizes and is physically associated with junctional proteins via its band 4.1/ezrin/radixin/moesin (FERM) domain, (Glading, 2007).
~ 84 kDa
Immunogen
Epitope: FERM domain
GST-tagged recombinant protein corresponding to human KRIT-1 at and around the FERM domain.
Application
Anti-KRIT-1 Antibody, clone 15 detects level of KRIT-1 & has been published & validated for use in IC, IP & WB.
Research Category
Cell Structure
Research Sub Category
Adhesion (CAMs)
Biochem/physiol Actions
The antibody recognizes KRIT-1.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
HeLa, A431, and HUVECs.
Immunocytochemistry Analysis: 1:500 dilution of this antibody detected KRIT-1 in HeLa, A431, and HUVECs.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | 15B2, monoclonal |
| species reactivity | human |
| technique(s) | immunocytochemistry: suitable,immunoprecipitation (IP): suitable |
| isotype | IgG2bκ |
| NCBI accession no. | NP_919436.1 |
| UniProt accession no. | O00522 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... KRIT1(889) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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