BioTracker DUAL dUTPase Live Cell reporter,1MG,SCT068,Sigma

销售价: ¥ 3904.65 / 件
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订货号 0BV8233
品牌型号 Sigma SCT068
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最小订货量 1件
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产品介绍 Product Description

General description

Nucleotide surveillance enzymes play important roles inhuman health, by monitoring damaged monomers in the nucleotide pooland deactivating them before they are incorporated into chromosomalDNA or disrupt nucleotide metabolism. Deamination ofcytosine, leading to uracil in DNA and in the nucleotide pool, can bedeleterious, causing DNA damage. The enzyme deoxyuridine triphosphatase(dUTPase) is the sole enzyme that cleanses the nucleotide pool of deaminated cytosine. Measuring the activity of this enzyme is importantboth in basic research and in clinical applications involving thispathway.The BioTracker DUAL dUTPase live cell probe is a luminescence probe that specifically reports on dUTPase activity in real time. The probe is a chimera of dUTP and ATP. dUTPase enzyme accepts the DUAL probe as an efficient substrate and upon hydrolysis releases ATP, which is detected sensitively by luciferase luminescence.Note: Luceferin and luciferase enzyme are needed to detect ATP released by hydrolysis, but are not included in this product. Spectral Properties:Luminescence intensity.Research Category:Live Cell Dye


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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial


技术参数 Specifications
formlyophilized
technique(s)activity assay: suitable
detection methodchemiluminescent
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