- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
TRAP lysate prepared from U937 cells
Product does not compete with ATP.
Reversible: yes
Target IC50: 670 nM against telomerase activity in TRAP lysate prepared from U937 cells
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Seimiya, H., et al. 2005. Cancer Cell7, 25.
Seimiya, H., et al. 2002. Mol. Cancer Ther.1, 657.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | DMSO: 5 mg/mL |
| shipped in | wet ice |
| storage temp. | −20°C |
| SMILES string | N(c2cc(ccc2)NC(=O)c3c(c(ccc3)O)O)C(=O)c1c(c(ccc1)O)O |
| InChI | 1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28) |
| InChI key | MIQUEZGHEJGPJB-UHFFFAOYSA-N |
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¥ 12156.68
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¥ 2290.21
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¥ 1476.00
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