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General description
TrpC3, also known as Short transient receptor potential channel 3, transient receptor protein 3 or TRP-3, and encoded by the gene TRPC3/TRP3, forms a receptor activated calcium channel that is activated via ligand binding and transduces signals via the G-protein coupled tyrosine receptor kinases pathways.TrpC3 can also be activated by the release of internal calcium and is one of the principal receptors involved in maintaining Ca++ ion homeostasis in skeletal muscles and nervous tissue. TrpC3 is also a principal receptor involved in the Capacitative calcium entry (CCE) which is the mechanism behind Ca++ influx into cells that replenishes internal calcium stores. Additionally, TrpC3 receptor is important in axon guidance, phototransduction, and platelet activation. TrpC3 is localized to the cell membrane and consists of a multipass-though transport protein. TrpC3 is expressed principally in the brain but is also found in most other tissues and organs at lowered levels.
~110 kDa observed.
Immunogen
Recombinant protein corresponding to mouse TrpC3.
Application
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
This Anti-TrpC3, clone 10H6 Antibody is validated for use in Western Blotting for the detection of TrpC3.
Western Blotting Analysis: A representative lot detected TrpC3 in cerebellar tissues of TRPC3 wild type mice and not TRPC3 knock out mice (Prof. Yizheng Wang, Shanghai Institutes for Biological Sciences (SIBS).
Western Blotting Analysis: A representative lot detected TrpC3 in rat liver and brain tissue lysates (Feng. S., et al. (2013). PNAS. 1-6).
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected TrpC3 in 10 µg of mouse brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 10H6, monoclonal |
| species reactivity | mouse |
| species reactivity (predicted by homology) | human (based on 100% sequence homology) |
| technique(s) | western blot: suitable |
| isotype | IgG1 |
| NCBI accession no. | NP_001124170 |
| UniProt accession no. | Q13507 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... TRPC3(7222) |
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¥ 916.08
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¥ 521.16
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¥ 1987.51
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¥ 1153.44
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¥ 1524.91
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¥ 661.45
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¥ 627.44
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¥ 633.78
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¥ 1212.50
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