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General description
150kDa Calculated
SMC (structural maintenance of chromosomes) proteins are Involved in chromosome cohesion during cell cycle and in DNA repair. ATM phosphorylates SMC1 on Ser957 and Ser966 both in vitro and in vivo. Phosphorylated SMC1 is part of the complex that functions as a downstream effector in both the ATM/NBS1 branch and the ATR/MSH2 branch of S-phase checkpoint.
Immunogen
Epitope: Phosphorylated at and around Ser957
KLH-conjugated, synthetic peptide corresponding to human SMC1 phosphorylated at Ser957
Application
Research Category
Epigenetics & Nuclear Function
Apoptosis & Cancer
Research Sub Category
Cell Cycle, DNA Replication & Repair
This Anti-phospho-SMC1 (Ser957) Antibody, clone 5D11G5 Alexa Fluor 488 is validated for use in WB, FC for the detection of phospho-SMC1 (Ser957).
Biochem/physiol Actions
Antibody recognizes SMC1 phosphorylolated at Ser957.
Predicted to cross-react with xenopus and bovine based on sequence homology
Physical form
Protein G Purified
Purified mouse monoclonal IgG1 conjugated to Alexa Flour
Preparation Note
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 6 months from date of receipt. Protect from light.
Analysis Note
Control
HeLa Cells
Evaluated by Flow Cytometry with Hela Cells
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | ALEXA FLUOR™ 488 |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 5D11G5, monoclonal |
| species reactivity | human, Xenopus, bovine |
| technique(s) | flow cytometry: suitable,western blot: suitable |
| isotype | IgG1 |
| NCBI accession no. | NM_006306 |
| UniProt accession no. | Q14683 |
| shipped in | wet ice |
| target post-translational modification | phosphorylation (pSer957) |
| Gene Information | human ... SMC1A(8243) |
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