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General description
TRIC-A (trimeric intracellular cation channel type A), also known as Tmem38A, and sometimes NET1, is one of a number of TRIC channel subtypes that are believed to function as a Ca2+ counter-ion channel. TRIC-A is highly expressed in excitable cells and seems to work in coordination with Ca2+ release to balance transient negative potential. TRIC-A is located on the sarcoplasmic reticulum (SR) and is thought to be regulated by trans-membrane voltage. TRIC-A deficiency may lead to an abundance of Ca2+ and cause volatility in Ca2+ movement across the SR membrane.
~33 kDa observed
Immunogen
Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRIC-A.
Application
Anti-TRIC-A Antibody detects level of TRIC-A & has been published & validated for use in WB, IH & IC.
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Wilkie, G.S., et al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1).
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Wilkie, G.S., et al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1).
Research Category
Epigenetics & Nuclear Function
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Biochem/physiol Actions
This antibody recognizes the cytoplasmic domain of TRIC-A.
Physical form
Affinity purified
Purified rabbit polyclonal in PBS containing 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Human fetal skeletal muscle tissue lysate.
Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TRIC-A on 10 µg of human fetal skeletal muscle tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human, mouse, rat |
| species reactivity (predicted by homology) | chimpanzee (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable,immunohistochemistry: suitable,western blot: suitable |
| NCBI accession no. | NP_076979.1 |
| UniProt accession no. | Q9H6F2 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... TMEM38A(79041) |
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