- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC50 = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120 ). Does not affect PKC or Chk2 kinase activities.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
DNA-PK activity
Product does not compete with ATP.
Reversible: no
Target IC50: 15 µM against DNA-PK (DNA-dependent protein kinase) activity
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Willmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res.31, 5501.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
| Quality Segment | 100 |
| assay | ≥90% (GC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | bright yellow |
| solubility | DMSO: 5 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [N+](=O)([O-])c1c(cc(c(c1)OC)OC)C=O |
| InChI | 1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3 |
| InChI key | YWSPWKXREVSQCA-UHFFFAOYSA-N |
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¥ 2013.69
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¥ 3275.78
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¥ 1509.00
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¥ 1301.36
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¥ 1586.69
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¥ 5804.96
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
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