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General description
Dopaminergic signals are thought to modulate corticostriatal synapses onto medium spiny projection neurons, and this plasticity is, in turn, thought to alter patterns of activity during learning. Subversion of these processes in clinical and rodent models is hypothesized to contribute importantly to addiction to psychostimulants, seizures, and movement disorders in Huntington’s (HD) and Parkinson’s disease (PD). Dopamine receptor D1, also known as DRD1, is the most abundant dopamine receptor (of the five types D1-D5) in the central nervous system and is critically involved in these processes and the modulation of D2 receptor mediated events. Coupled with G-protein, the D1a receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases including the key molecular switch, DARPP-32.
~ 55 kDa is observed
Immunogen
Epitope: Cytoplasmic Domain
KLH-conjugated linear peptide of rat dopamine D(1A) receptor at and around the cytoplasmic domain.
Application
Anti-Dopamine D(1A) Receptor Antibody detects level of Dopamine D(1A) Receptor & has been published & validated for use in IH, WB, ELISA.
Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected D(1A) dopamine receptor in rat brain tissue.
ELISA Analysis: Tested in ELISA against antigen-coated plate. A 1:100 dilution from a previous lot detected dopamine D(1A) receptor peptide.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Biochem/physiol Actions
This antibody recognizes D(1A) dopamine receptor.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Rat testis tissue lysate
Evaluated by Western Blot in rat testis tissue lysate.
Western Blot Analysis: 2 µg/ml of this antibody detected dopamine D(1A) receptor in 10 µg of rat testis tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB1765P;
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | rat |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable,ELISA: suitable,western blot: suitable |
| NCBI accession no. | NP_036678 |
| UniProt accession no. | P18901 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | rat ... Drd1(24316) |
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