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General description
An alpha-aminoaralkylphosphonic acid ester that acts as an aminopeptidase N/CD13 inhibitor (IC50=1.1 µM). Cell growth is dose dependently inhibited by as much as ~36% and ~60% in PANC-1 and HT-1080 cells, respectively when 300 µM of compound 4d is co-treated with 30 µg/ml of TNF. When treated with compound 4d alone, cell growth is dose-dependently inhibited by as much as 26% and 36%, in the same cell lines, respectively.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Grzywa, R., et al. 2010. Bioorg. Med. Chem.8, 2930.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Level | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| color | white |
| solubility | 0.1 M NaOH: 1 mg/mL,DMSO: 1 mg/mL (Only partially soluble),water: 1 mg/mL (only partially soluble) |
| shipped in | wet ice |
| storage temp. | −20°C |
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询价
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¥ 459.57
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¥ 1011.55
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¥ 1665.68
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¥ 629.40
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¥ 1327.84
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¥ 619.92
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¥ 478.46
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¥ 1147.95
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¥ 911.06
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