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Anti-ZCCHC11 (TUT4) Antibody, clone 9F6.1，100UG，MABE1526，Sigma

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订货号： 0BV6779

品牌型号： Sigma MABE1526

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最小订货量： 1件

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产品介绍 Product Description

General description

Terminal uridylyltransferase 4 (EC 2.7.7.52; UniProt Q5TAX3; also known as TUTase 4, Zinc finger CCHC domain-containing protein 11) is encoded by the ZCCHC11 (also known as KIAA0191, TUT4) gene (Gene ID 23318) in human. TUTase 4 is an uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. It is involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets and also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, and miR-143 and miR-200c. It is reported to catalyze the 3′ uridylation of miR-26A that targets IL6 transcript to abrogate the silencing of IL6 transcript and promote cytokine expression. It may also participate in toll-receptor signaling by suppressing TRAF6-dependent activation of NF-kappaB.

~185 kDa observed. 185.2/81.14 kDa (human isoform 1/2) calculated. Uncharacterized bands may be observed in some lysate(s).

Immunogen

GST-tagged recombinant human ZCCHC11 (TUT4) N-terminal fragment.

Application

Anti-ZCCHC11 (TUT4), clone 9F6.1, Cat. No. MABE1526, is a highly specific mouse monoclonal antibody that targets ZCCHC11 (TUT4) and has been tested in Western Blotting.
Research Category
Epigenetics & Nuclear Function
Western Blotting Analysis: 4 µg/mL from a representative lot detected ZCCHC11 (TUT4) in 10 µg of C2C12 mouse myoblast and Jurkat human T-cell lysates.

Biochem/physiol Actions

Clone 9F6.1 targets an epitope in the N-terminal region of ZCCHC11 (TUT4).

Physical form

Format: Purified
Protein G purified.
Purified mouse IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Western Blotting in PC3 cell lysate.

Western Blotting Analysis: 4 µg/mL of this antibody detected ZCCHC11 (TUT4) in 10 µg of PC3 human prostate cancer cell lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	mouse
Quality Segment	100
conjugate	unconjugated
antibody form	purified immunoglobulin
antibody product type	primary antibodies
clone	9F6.1, monoclonal
species reactivity	human, mouse
technique(s)	western blot: suitable
isotype	IgG1κ
NCBI accession no.	NP_056084
UniProt accession no.	Q5TAX3
shipped in	ambient
target post-translational modification	unmodified
Gene Information	human ... ZCCHC11(23318)

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