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General description
Androgen receptor (UniProt P15207; also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4) is encoded by the Ar (also known as Andr, Nr3c4, Tfm) gene (Gene ID 24208) in rat species. Androgen receptor (AR) is a hormone-activated transcription regulator that plays important roles in normal prostate development and function, as well as in malignant prostate transformation. The binding of an androgenic hormone (testosterone or dihydrotestosterone) induces a conformational change in AR, resulting its dissociation from heat schock proteins and subsequent translocation from the cytosol to nucleus, where it dimerizes and mediates either transcription activation or repression in a target gene-specific manner. The androgen insensitivity syndrome (AIS) or testicular feminization (TFM) is caused by a mutation of the androgen receptor gene located on the X chromosome.
~110 kDa observed.
Immunogen
Epitope: This antibody recognizes the Modulating Region within the N-terminal of androgen receptor.
KLH-conjugated linear peptide corresponding to the N-terminal sequence of rat androgen receptor.
Application
Detect Androgen Receptor using this Anti-Androgen Receptor Antibody, Alexa Fluor™ 647 Conjugate validated for use in Immunocytochemistry.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Hormones & Receptors
The unconjugated antibody (Cat. No. 06-680) is shown to be suitable also for chromatin immunoprecipitation (ChIP), ChIP-seq, Western blotting, immunoprecipitation, flow cytometry, immunohistochemistry applications.
Physical form
Affinity purified
Purified rabbit polyclonal antibody conjugate in PBS with 15 mg/mL BSA and 0.1 % sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Immunocytochemistry in MCF-7 cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Androgen Receptor in MCF-7 cells.
Other Notes
Concentration: Please refer to lot specific datasheet.
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | ALEXA FLUOR™ 647 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | rat, human |
| species reactivity (predicted by homology) | canine (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology), horse (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable |
| NCBI accession no. | NP_036634 |
| UniProt accession no. | P15207 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | bovine ... Ar(280675) dog ... Ar(403588) human ... AR(367) mouse ... Ar(11835) rat ... Ar(24208) |
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