- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. Acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Appears to bind to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
N-WASP (neural Wiskott Aldrich syndrome protein)
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Peterson, J.R., et al. 2004. Nat. Struct. Mol. Biol.11, 747.
Peterson, J.R., and Mitchison, T.J. 2002. Chem. Biol.9, 1275.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | white |
| solubility | DMSO: 5 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | Brc1cc2c([n](c3c2cc(cc3)Br)CC(O)CN(C)C)cc1 |
| InChI | 1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3 |
| InChI key | XUBJEDZHBUPBKL-UHFFFAOYSA-N |
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