- 商品介绍
- 规格参数
- 包装参数
General description
Calretinin (UniProt: P47728; also known as CR) is encoded by the Calb2 gene (Gene ID: 117059) in rat. Calretinin belongs to the calbindin protein family and acts as a calcium-binding protein. It is expressed in both central and peripheral nervous system and is found abundantly in auditory neurons. It is involved in regulating cytosolic calcium ion concentrations and has multiple calcium-binding domains known as EF-hands. Its expression is shown to be regulated at the level of transcription by nuclear respiratory factor 1 (NRF-1) and E2F2 transcription factors. In rat striatum calretinin neurons form a distinct subset of medium-sized (7 20 µm), aspiny, GABAergic interneurons. Calretinin can also serve as an important differential diagnostic tool for cystic and solid ameloblastic tumors. (Ref.: Petryszyn, S., et al. (2017). J. Neural Transm. doi: 10.1007/s00702-017-1687; Kresoja-Rakic, J., et al. (2017). Front. Genet. doi: 10.3389/fgene.2017.00070).
~31 kDa observed; 31.41 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Immunogen
Epitope: domain of:
GST/His-tagged recombinant fragment corresponding to 99 amino acids from the internal region of rat Calretinin.
Application
Anti-Calretinin Antibody, Cat. No. ABN2191, is a highly specific rabbit polyclonal antibody that targets Calretinin and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Research Category
Neuroscience
Western Blotting Analysis: A 1:500 dilution from a representative lot detected Calretinin in rat brain tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Calretinin in human cerebral cortex and rat cerebellum tissue sections.
Biochem/physiol Actions
This rabbit polyclonal antibody detects Calretinin in human and rat cells. It targets an epitope within 99 amino acids from the internal region.
Physical form
Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human fetal brain tissue lysate.
Western Blotting Analysis: A 1:500 dilution of this antibody detected Calretinin in human fetal brain tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human, rat |
| packaging | antibody small pack of 25 μL |
| technique(s) | immunohistochemistry: suitable (paraffin),western blot: suitable |
| isotype | IgG |
| web metadata keyword.default | Calb2 protein antibody for immunohistochemistry,Calretinin antibody for auditory neuron research,Calretinin antibody for western blot,Calretinin antibody with EF-hand domains,Calretinin immunohistochemistry antibody,Sigma-Aldrich anti-Calretinin antibody,anti-CR antibody PA5-16681,anti-Calretinin antibody AB16694,anti-Calretinin antibody for paraffin sections,anti-Calretinin antibody for rat tissue,anti-Calretinin antibody,anti-Calretinin for calcium-binding protein studies,high purity Calretinin antibody for research,rat Calretinin gene ID 117059 antibody |
| NCBI accession no. | NM_001740.3 |
| UniProt accession no. | P47728 |
| shipped in | ambient |
| target post-translational modification | unmodified |
| Gene Information | human ... CALB2(794) |
| 长度(mm) | |
| 宽度(mm) | |
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