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- 规格参数
- 包装参数
General description
A cell permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 75 nM). Also inhibits Ras farnesylation in whole cells by ~90% at 25-250 µM. Resistant to cleavage by phosphorylation.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
A highly selective and potent inhibitor of Ras farnesyltransferase (IC50 = 75 nM). Inhibits geranylgeranyltransferase I (IC50 = 24 µM) and II (IC50 = 24 µM) at much higher concentrations. Also inhibits Ras farnesylation in whole cells by ~90% at 10-100 µg/ml (25-250 µM). Resistant to cleavage by phosphorylation.
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC50: 75 nM against Ftase
Other Notes
Manne, V., et al. 1995. Drug Development Res.34, 121.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic) |
| color | white |
| solubility | water: ≥10 mg/mL |
| shipped in | ambient |
| storage temp. | −20°C |
| 长度(mm) | |
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¥ 1302.89
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¥ 1451.54
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¥ 4968.78
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¥ 2842.54
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¥ 5014.59
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¥ 2406.69
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¥ 3896.11
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¥ 9909.51
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¥ 17652.29
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¥ 58855.47
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