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General description
Neuregulin isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9). Neuregulin Type I/II serve as direct ligands for ERBB3 and ERBB4 tyrosine kinase receptors that regulate development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Type I isoforms are the predominant forms expressed in the endocardium. Type II is the major form in skeletal muscle cells, and is expressed in the spinal cord, brain, adult heart, placenta, lung, liver, kidney, and pancreas. Neuregulin-HBD refers to the heparin binding domain of Type I/II Neuregulin.
~110 and ~58 kDa observed. May detect multiple isoforms (Alpha1A, Alpha2B, Alpha3; and Beta1/1A, Beta2, Beta3).
Immunogen
Epitope: Extracellular domain
GST-tagged recombinant protein corresponding to the extracellular domain of human Pro-neuregulin-1, membrane-bound isoform (NRG1).
Application
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Pro-neuregulin-1, membrane-bound isoform (NRG1) in human cardiac myocytes and human cerebellum tissue.
Research Category
Cell Structure
Research Sub Category
Adhesion (CAMs)
This Anti-Pro-neuregulin-1, membrane-bound isoform (NRG1 Antibody) is validated for use in Western Blotting and Immunohistochemistry for the detection of Pro-neuregulin-1, membrane-bound isoform (NRG1).
Biochem/physiol Actions
This antibody is expected to cross-react to all Alpha and Beta isoforms (Alpha1A, Alpha2B, Alpha3; and Beta1/1A, Beta2, Beta3), also known as Type I.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in PC3 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Pro-neuregulin-1, membrane-bound isoform (NRG1) in 10 µg of PC3 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | chimpanzee (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| NCBI accession no. | NP_001153467 |
| UniProt accession no. | Q02297 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... NRG1(3084) |
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