- 商品介绍
- 规格参数
- 包装参数
General description
AMPK (α2, β1, γ1)
Recombinant, human AMPK (α2, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα2, full length untagged AMPKβ1 and full length untagged AMPKγ1.
Application
Research Category
Metabolism
Apoptosis & Cancer
Research Sub Category
Diabetes
Obesity
Metabolic Disorders
Biochem/physiol Actions
Protein Target: AMPK (α2, β1, γ1)
Target Sub-Family: CAMK
Packaging
Also available in 10 μg size and in bulk
Also available in 250µg size as catalog # 14-902M - Call for pricing and availability.
Physical form
Cobalt-agarose
Preparation Note
6 months at -70°C
Analysis Note
Routinely evaluated by phosphorylation of substrate peptide
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | human |
| Quality Level | 100 |
| recombinant | expressed in E. coli |
| product line | Upstate® |
| specific activity | (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.) |
| mol wt | Mw 30 kDa (AMPKβ1),Mw 38 kDa (AMPKγ1),Mw 63 kDa (AMPKα2) |
| purified by | (Ni2+/NTA-agarose) |
| species reactivity | human |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable (kinase) |
| accession no. | (Function: Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5′-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit. ),NM_006252 |
| NCBI accession no. | NM_002733,NM_006252,NM_006253 |
| UniProt accession no. | P54619,P54646,P54646, Q9Y478, P54619,Q9Y478 |
| relevant disease(s) | diabetes; obesity; metabolic disorders |
| Gene Information | human ... PRKAA2(5563), PRKAB1(5563) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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