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E-4031，5MG，324470-5MGCN，Sigma

销售价： ¥ 4817.50 / 件

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订货号： 0BV4510

品牌型号： Sigma 324470-5MGCN

货期：询货期

最小订货量： 1件

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商品介绍
规格参数
包装参数

产品介绍 Product Description

General description

A potent and selective inhibitor of the inactivating inward-rectifying potassium current (IK,IR) (IC₅₀ = 10 nM). In inside-out patches, E-4031 also blocks ATP sensitive K⁺ channel (EC₅₀ = 31 µM). A specific blocker of cardiac HERG channels (IC₅₀ = 7.7 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity.
A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K⁺ current (IK, IR) (IC₅₀ = 10 nM). A class III anti-arrhythmic agent with differential atrial versus ventricular activity. A specific blocker of HERG channels (IC₅₀ = 7.7 nM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inhibitor of the rapid type of inactivating inward-rectifying K+ current
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 10 nM inhibiting the rapid type of inactivating inward-rectifying K+ current

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ficker, E., et al. 2000. Am. J. Physiol.279, H1748.
Ono, K., et al. 2000. J. Physiol. (London)524 (Pt. 1), 51.
Xie, J.T., et al. 2000. Methods Find. Exp. Clin. Pharmacol.22, 67.
Bauer, C.K., et al. 1999. Mol. Cell Endocrinol. 148, 37.
Baskin, E.P., and Lynch, J.J. 1998. J. Pharmacol. Exp. Ther. 285, 135.
Weinsberg, F., et al. 1997. Pflugers Arch. 434, 1.
West, P.D., et al. 1997. J. Cardiovasc. Pharmacol. Ther.2, 205.
West, P.D., et al. 1996. Pharmacol. Toxicol.78, 89.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

技术参数 Specifications

Quality Level	100
assay	≥98% (HPLC)
form	solid
manufacturer/tradename	Calbiochem^®
storage condition	OK to freeze,desiccated (hygroscopic)
color	white to off-white
solubility	DMSO: 50 mg/mL,water: 50 mg/mL
shipped in	ambient
storage temp.	−20°C
SMILES string	[S](=O)(=O)(Nc1ccc(cc1)C(=O)C2CCN(CC2)CCc3nc(ccc3)C)C
InChI	1S/C21H27N3O3S/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27/h3-9,18,23H,10-15H2,1-2H3
InChI key	SRUISGSHWFJION-UHFFFAOYSA-N

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