- 商品介绍
- 规格参数
- 包装参数
General description
Research area: Cell Signaling
Recombinant, full-length, human MAP Kinase 1/Erk1 containing an N-terminal GST tag
Biochem/physiol Actions
Extracellular-signal-regulated kinase 1 (ERK1)/ Extracellular-signal-regulated kinase 2 (ERK2), as part of the Ras-Raf-MEK-ERK signal transduction cascade, are involved in regulating a wide range of cellular processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcriptional control. Additionally, ERK1 signaling contributes to the regulation of cyclin D1 expression during the cell cycle. MAP kinases play a crucial role in inflammation and immune responses by regulating the production of pro- and anti-inflammatory cytokines, as well as prostaglandins, in response to lipopolysaccharide (LPS) stimulation.
Packaging
Also available in 250μg size as catalog # 14-439M - Call for pricing and availability.
Physical form
Purified by glutathione-agarose. Activated with MEK1 and repurified on Ni2+/NTA agarose
Analysis Note
routinely evaluated by phosphorylation of MBP
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
| biological source | human |
| Quality Segment | 100 |
| recombinant | expressed in E. coli |
| form | liquid |
| mol wt | Mw 69.9 kDa |
| manufacturer/tradename | Upstate® |
| technique(s) | activity assay: suitable (kinase) |
| color | colorless |
| solubility | water: soluble |
| web metadata keyword.default | 10 µg MAP Kinase 1 Erk1 for extracellular signaling,Erk1 kinase active form for research,GST-tagged recombinant MAP Kinase 1 Erk1 10 µg,MAP Kinase 1 Erk1 enzyme,MAP Kinase 1 Erk1 protein,MAPK1 activity assay reagent 10 µg,MAPK1 protein 10 µg,MAPK1 protein for protein interaction studies,MAPK1 protein with GST tag for biochemical assays,MAPK1 recombinant protein for cell signaling research,MAPK1/ERK1 protein assay reagent,active MAP Kinase 1 Erk1 protein 10 µg,human MAP Kinase 1 active protein 10 µg,purified Erk1 protein for activity assay,research-grade MAP Kinase 1 Erk1 protein |
| NCBI accession no. | NM_002745.4,NM_138957.3 |
| UniProt accession no. | P28482 |
| Gene Information | human ... MAPK3(5595) |
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¥ 2528.88
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¥ 1563.36
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¥ 238.17
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¥ 15214.65
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¥ 1564.00
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¥ 5014.59
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¥ 2277.64
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