- 商品介绍
- 规格参数
- 包装参数
General description
A water-soluble form of the potent MAP kinase inhibitor SB 203580 (Cat. No. 559389).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
p38 MAP kinase
Product does not compete with ATP.
Reversible: no
Target IC50: 34 nM against p38 MAP kinase in vitro, 600 nM in cells; 50-100 nM against IL-1 and TNF-a production from LPS-stimulated human monocytes and the human monocyte cell line THP-1; 0.2-1.0 µM against platelet aggregation caused by collagen
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥95% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| color | bright yellow |
| solubility | water: 10 mg/mL,DMSO: soluble |
| web metadata keyword.default | 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole HCl,SB 203580 HCl stock solution preparation,SB 203580 hydrochloride 100mg for biochemical assays,SB 203580 hydrochloride 869185-85-3,SB 203580 hydrochloride cell permeable inhibitor,SB 203580 hydrochloride for pharmaceutical research,SB 203580 hydrochloride reconstitution guidelines,SB 203580 hydrochloride stability at -20°C,SB 203580 hydrochloride,Sigma-Aldrich SB 203580 hydrochloride 25mg,high-purity SB 203580 hydrochloride,lab-grade SB 203580 hydrochloride for research,p38 MAP Kinase inhibitor SB 203580 hydrochloride |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | Fc1ccc(cc1)c2[nH]c(nc2c4ccncc4)c3ccc(cc3)[S](=O)C.Cl |
| InChI | 1S/C21H16FN3OS.ClH/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15;/h2-13H,1H3,(H,24,25);1H |
| InChI key | WOSGGXINSLMASH-UHFFFAOYSA-N |
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