- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable pyrrolopyridinyl compound that acts as a potent, selective, and ATP-biniding site-targeting MK-2/MAPKAP-K2 inhibitor (IC50 = 8.5, 81, and 210 nM agaisnt MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Anderson, D.R., et al. 2007. J. Med. Chem.50, 2647.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | pale yellow |
| solubility | DMSO: 50 mg/mL |
| shipped in | ambient |
| storage temp. | 2-8°C |
| SMILES string | [nH]1c2c(cc1c3cc(ncc3)c4cnc5c(c4)cccc5)C(=O)NCC2.O |
| InChI key | NIKCVKMHGQQSRN-UHFFFAOYSA-N |
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