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General description
Muscleblind 1 (MBNL1) is a member of the muscleblind family. MBNL1in involved in pre-mRNA alternative splicing and acts as either splicing activator or repressor on specific pre-mRNA targets. This protein contains four C3H1-type zinc fingers and binds to expanded CUG repeat RNA. High expression of MBNL1 has been observed in cardiac and skeletal muscle as well as in differentiating myoblasts. MBNL1 is known to be involved in the pathogenesis of dystrophia myotonica type 1 (DM1). For those afflicted with this muscular disorder, MBNL1 is sequestered by DMPK RNAs that contain CUG triplet repeat expansions.
~ 33-42 kDa observed. There are three known splice variants ranging from ~33 kDa to ~42 kDa An uncharacterized band at ~ 80 kDa has been observed in some lysates.
Immunogen
Histidine-tagged recombinant protein corresponding to human MBNL1.
Application
Research Category
Epigenetics & Nuclear Function
Research Sub Category
RNA Metabolism & Binding Proteins
Use Anti-MBNL1 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect MBNL1 also known as muscleblind-like (Drosophila), Triplet-expansion RNA-binding protein.
Physical form
Purified rabbit polyclonal in tris-citrate containing 0.1% sodium azide.
Affinity purified
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
A431 cell lysate
Evaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected MBNL1 on 10 µg of A431 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | mouse, human, rat |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_066368 |
| UniProt accession no. | Q9NR56 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... MBNL1(4154) |
| 长度(mm) | |
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