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General description
GBP5, also known as GBP-TA antigen, or GTP-binding protein 5, or Guanine nucleotide-binding protein 5 or GBP-5, and encoded by the gene GBP5, is a protein that plays a role in the inflammatory response to pathogens and may also play a role in apoptosis. GBP5 stimulates cryopryrin (NLRP3 protein) assembly of the intracellular inflammasome, a multiprotein oligomer consisting of caspase 1, PYCARD, NALP and sometimes caspase 5. Inflammasomes act as sensory complexes that alert the immune system to the presence of infection or tissue damage. Nucleosomes and GBP5 are expressed in myeloid cells and are a component of the innate immune system; GBP5 acts as key rheostat for activation and assembly of the inflammasomes. Additionally, GBP5 is a GTPase that homodimerizes upon GTP-binding; dimerization is required for the second hydrolysis step from GDP to GMP. GBP5 is localized to the cytoplasm and intracellular membranes via its lipid-anchor sequences.
~67 kDa observed. A second isoform is known to exist at 55 kDa Uncharacterized band(s) may be observed in some cell lysates.
Immunogen
Linear peptide corresponding to human GBP5.
Application
Detect GTP binding protein using this rabbit polyclonal antibody, Anti-GBP5 Antibody validated for use in western blotting.
Research Category
Signaling
Research Sub Category
Immunological Signaling
Western Blotting Analysis: A representative lot from an independent laboratory detected GBP5 in differentiating THP-1 cells which were untreated or treated with LPS alone, or LPS/IFN-gamma (Shenoy, A. R., et al. (2012). Science. 336(6080):481-485.).
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in K562 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected GBP5 in 10 µg of K562 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| technique(s) | western blot: suitable |
| NCBI accession no. | NP_001127958 |
| UniProt accession no. | Q96PP8 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... GBP5(115362) |
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¥ 2013.69
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¥ 4039.86
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¥ 205945.25
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