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General description
一种非特异性磷脂酶A2 (PLA2)抑制剂。作为乙酰胆碱受体拮抗剂。抑制格列本脲敏感的K+-电流 (IC50 = 4.4 µM)。还抑制单胺氧化酶（MAO）。
Biochem/physiol Actions
产物不与ATP竞争。
可逆：否
细胞可渗透性：否
非选择性 MAO-A/B 抑制剂。
靶标IC50：4.4 µM，抑制格列本脲敏感的K+-电流
Preparation Note
贮备溶液在20°C下可稳定保存至多60个月。
Other Notes
Holscher, C. 1995.Neurobiol.Learn.Mem.63, 206.
Sakuta, H. and Yoneda, I. 1994.Eur. J. Pharmacol.252, 117.
Sargent, C.A., et al 1992.J. Pharmacol.Exp.Ther.262, 1161.
Voorhis, B.J., et al. 1992.Invertebr.Reprod.Dev.21, 33.
Murakami, M., et al. 1991.Biochem.Biophys.Res. Commun.181, 714.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：有害（C）
| Quality Segment | 100 |
| description | Merck USA index - 14, 8044 |
| assay | ≥98% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| color | yellow |
| solubility | water: soluble |
| shipped in | ambient |
| storage temp. | 10-30°C |
| SMILES string | Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13 |
| InChI | 1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H |
| InChI key | UDKVBVICMUEIKS-UHFFFAOYSA-N |
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