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General description
BM88/Cend1, also known as Cell cycle exit and neuronal differentiation protein 1, or BM88 antigen, and encoded by the gene Cend1/BM88, is a neuronal specific membrane protein that is involved in neuronal development. BM88/Cend1 is particularly important in cerebellar development including Purkinje cell differentiation as well as radial glia guided migration of cerebellar granule cell development. Overexpression of BM88/CEND1 in transplanted neural stem cells also appears to enhance the regeneration of neuronal cells in injured rodent brains. BM88/Cend1 function is at least partially mediated through interacting with the important developmental protein Ahi1, and research indicates that BM88/Cend1 is also involved in Ahi1-associated hypothalamic neuronal differentiation in early development.
~19 kDa observed
Immunogen
Epitope: Cytoplasmic domain
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human BM88/Cend1.
Application
Anti-BM88/Cend1 Antibody, clone 4A3.1 is an antibody against BM88/Cend1 for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50-2,000 dilution from a representative lot detected BM88/Cend1 in human cerebellum, human thalamus sections, and rat cerebral cortex tissue.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human cortex tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected BM88/Cend1 in 10 µg of human cortex tissue lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 4A3.1, monoclonal |
| species reactivity | human |
| concentration | 1 mg/mL |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_057648 |
| UniProt accession no. | Q8N111 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... CEND1(51286) |
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