- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Also available as a 10 mM solution in DMSO (Cat. No. 5.05378).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
IKK
Product competes with ATP.
Reversible: no
Target IC50: 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively
Packaging
Packaged under inert gas
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
| Quality Segment | 100 |
| assay | ≥97% (HPLC) |
| form | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,protect from light |
| color | pale yellow |
| solubility | DMSO: 10 mg/mL |
| web metadata keyword.default | 10 mM IKK Inhibitor VII DMSO solution,ATP-competitive IKK inhibitor,IKK 16 inhibitor 873225-46-8,IKK Inhibitor VII Sigma-Aldrich,IKK Inhibitor VII for biomedical research,IKK Inhibitor VII for in vivo studies,IKK Inhibitor VII procurement,IKK Inhibitor VII research chemical,IKK Inhibitor VII,IKK inhibitor for NF-kB gene expression studies,IKK inhibitor for cellular IκBα degradation,cell-permeable IKK inhibitor for HUVEC cells,high-purity IKK Inhibitor VII for laboratories,potent IKK inhibitor 40 nM IC50,selective IKK inhibitor |
| shipped in | wet ice |
| storage temp. | −20°C |
| SMILES string | [s]1c2c(cc1c3nc(ncc3)Nc4ccc(cc4)C(=O)N5CCC(CC5)N6CCCC6)cccc2 |
| InChI | 1S/C28H29N5OS/c34-27(33-17-12-23(13-18-33)32-15-3-4-16-32)20-7-9-22(10-8-20)30-28-29-14-11-24(31-28)26-19-21-5-1-2-6-25(21)35-26/h1-2,5-11,14,19,23H,3-4,12-13,15-18H2,(H,29,30,31) |
| InChI key | BWZJBXAPRCVCKQ-UHFFFAOYSA-N |
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¥ 9207.92
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¥ 3109.49
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