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Biochem/physiol Actions
AA-263 is a cell penetrant, potent and selective ATF6 activator that corrects the trafficking, conformation, secretion, and function of AAT-Z. AA-263 increases AAT neutrophil elastase (NE) inhibitory activity, while reducing polymer accumulation for the majority of AATD (alpha-1 antitrypsin (AAT) causes AAT deficiency) variants.
Cell penetrant, potent and selective ATF6 activator that corrects the trafficking, conformation, secretion, and function of AAT-Z
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | , Faint orange to Red |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | [N+](=O)([O-])c1ccc(cc1)N\N=C\c2c(cccc2)O |
| InChI | 1S/C13H11N3O3/c17-13-4-2-1-3-10(13)9-14-15-11-5-7-12(8-6-11)16(18)19/h1-9,15,17H/b14-9+ |
| InChI key | VQIJGQPVYQKSSH-NTEUORMPSA-N |
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¥ 2707.32
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¥ 2013.69
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¥ 9207.92
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